DVD/240149 -Vaccine effectiveness, burden and impact studies

The European Centre for Disease Prevention and Control (ECDC) has issued a call for tenders (ECDC/2025/OP/0002) aimed at conducting vaccine effectiveness, disease burden, and impact studies. This opportunity is organized into two separate lots, with a total estimated value of €29,500,000.

Lot 1, valued at €20,000,000, focuses on primary data collection in hospital and primary care settings, which includes:
- Conducting studies on vaccine effectiveness, disease burden, and related impacts for different age groups and special populations using the existing VEBIS hospital network.
- Performing similar studies in primary care settings.
- Addressing additional ad hoc studies related to these areas, potentially including zoonotic disease exposure scenarios.

Lot 2, estimated at €9,500,000, will utilize Electronic Health Registries (EHR) to conduct similar studies more efficiently.

This procurement is classified as a framework contract, meaning there is a long-term relationship established between ECDC and the selected contractors. The tender is open for submissions, which must be made electronically, and is structured to follow the best price-quality ratio evaluation method, leveraging a 60% quality and 40% price weighting.

The publication date for this tender is October 30, 2025, with a submission deadline of December 16, 2025, at 16:00 CET. The tender's public opening is scheduled for December 18, 2025, at 12:00 CET. Organizations interested in participating must obtain a Participant Identification Code (PIC) and can either apply individually or as a consortium.

The project is not suited for small and medium-sized enterprises (SMEs), as indicated by the eligibility data. The funding mechanism involves payments made for services rendered, reflecting a procurement contract rather than grant funding.

Applicants should prepare for a comprehensive evaluation process, focusing on their capabilities to execute complex research projects in the health sector. The framework allows for flexible commissioning of studies as required by evolving public health needs in Europe. Interested parties are urged to review the more detailed documentation provided by ECDC for specific requirements related to tender submissions.

The European Centre for Disease Prevention and Control (ECDC) has published a call for tenders, ECDC/2025/OP/0002, for vaccine effectiveness, disease burden, and impact studies. The TED reference for this call is 209/2025 719951-2025. The estimated total value for this tender is 29,500,000 EUR. The procedure type is an open procedure, and submissions must be electronic. The main classification (CPV) is 85100000 - Health services. The TED publication date is 30/10/2025. The deadline for receipt of tenders is 16/12/2025 at 16:00 Europe/Stockholm. The date and time of the public opening is 18/12/2025 12:00 Europe/Stockholm. The contracting authority is not bound to reply to questions submitted after 08/12/2025 07:00 Europe/Stockholm. The maximum contract duration is 48 months. The award method is based on the best price-quality ratio. This is a framework agreement without reopening of competition.

The tender is divided into two lots:

Lot 1: Vaccine effectiveness, disease burden and impact studies using primary data in the hospital and primary care setting. The estimated value for Lot 1 is 20,000,000 EUR. This lot includes three work areas:

Work area 1: Vaccine effectiveness, disease burden and impact studies in the hospital setting (all age groups and including special populations), by building on the existing VEBIS hospital network.
Work area 2: Vaccine effectiveness, disease burden and impact studies in the primary care setting (all age groups, special populations), by building on the existing VEBIS primary care network.
Work area 3: Additional and ad hoc studies within the hospital and primary care setting. This work area can also be used for additional settings, for example those where there is exposure to infected animals or to an environment in which infected birds or animals are or have been present, e.g. for assessing VE against zoonotic influenza.

Lot 2: Vaccine effectiveness, disease burden and impact studies using mainly Electronic Health Registries. The estimated value for Lot 2 is 9,500,000 EUR.

The following documents are available for download:

Invitation to tender ECDC2025OP0002 Vaccine effectiveness studies Invitation letter, published on 30/10/2025, Version 1, for all lots.
ENTS Part1 ECDC2025OP0002 Vaccine effectiveness studies Tender specifications - adm. part, published on 30/10/2025, Version 1, for all lots.
ENTS Part2 Technical Specifications ECDC2025OP0002 Technical specifications, published on 30/10/2025, Version 1, for all lots.
Draft FWC ECDC2025OP0002 LOT1 Draft contract, published on 30/10/2025, Version 1, for Lot 1.
Draft FWC ECDC2025OP0002 LOT2 Draft contract, published on 30/10/2025, Version 1, for Lot 2.
Annex 6a- LOT1 Financial tender Financial offer form, published on 30/10/2025, Version 1, for Lot 1.
Annex 6b- LOT2 Financial tender Financial offer form, published on 30/10/2025, Version 1, for Lot 2.

Submissions must be sent exclusively via electronic submission.

Some frequently asked questions (FAQ) and their answers are provided regarding the eSubmission system:

How to proceed if the system is slow or doesn’t work while uploading/downloading documents? Use the latest versions of Google Chrome or Mozilla Firefox. Clear the cache and cookies on the Internet browser.
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Where can I find my submissions in Manage My Area, in the Funding & Tenders portal? In ‘My Submission(s)’: tenders in response to open calls for tenders, requests to participate.
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In summary, this is a call for tenders issued by the ECDC for studies related to vaccine effectiveness, disease burden, and impact. The tender is divided into two lots, one focusing on primary data from hospitals and primary care settings, and the other focusing on electronic health registries. The total estimated value is 29.5 million EUR, and the contracts awarded will be framework agreements lasting up to 48 months. Interested parties must submit their tenders electronically by December 16, 2025, and should consult the provided documentation for detailed technical specifications and administrative requirements. A key requirement for participation is obtaining a Participant Identification Code (PIC). The eSubmission system supports various file types and languages, and encrypts submitted documents for confidentiality.

Eligible Applicant Types: The eligible applicant types are not explicitly stated, but given the nature of the tender, it is likely that eligible applicants include research institutes, universities, health organizations, and other entities with expertise in vaccine effectiveness studies, disease burden analysis, and public health research. The requirement for a PIC (Personal Identification Code) suggests that the applicants must be organizations rather than individuals.

Funding Type: The funding type is procurement, specifically a service contract. The call is an invitation to tender, and the selected tenderers will be awarded a framework agreement to provide services related to vaccine effectiveness studies.

Consortium Requirement: The content mentions that a PIC is mandatory to participate in a call for tenders as a sole candidate/tenderer or as a member of a group (consortium). This suggests that both single applicants and consortia are eligible to apply.

Beneficiary Scope (Geographic Eligibility): The geographic eligibility is not explicitly mentioned, but given that it is an ECDC (European Centre for Disease Prevention and Control) tender, it is highly likely that the primary target is EU and EEA countries.

Target Sector: The target sector is health, specifically vaccine effectiveness, disease burden, and impact studies. The tender focuses on public health research related to vaccine-preventable diseases and zoonotic influenza.

Mentioned Countries: No specific countries are mentioned, but the context implies that the opportunity is focused on the EU and potentially EEA countries, given the involvement of the European Centre for Disease Prevention and Control (ECDC).

Project Stage: The expected maturity of the project is likely to be at the stage of development and validation, focusing on conducting studies and analyzing data related to vaccine effectiveness and disease burden. The tender aims to build upon existing networks like VEBIS, suggesting that some groundwork has already been laid.

Funding Amount: The estimated total value for both lots is 29,500,000 EUR. Lot 1 has an estimated value of 20,000,000 EUR, and Lot 2 has an estimated value of 9,500,000 EUR.

Application Type: The application type is an open call for tenders, with electronic submission required.

Nature of Support: Beneficiaries will receive money in exchange for services rendered, as this is a procurement contract. The selected tenderers will be providing vaccine effectiveness studies and related services to the ECDC.

Application Stages: The number of application stages is not explicitly mentioned, but it can be inferred that there will be at least two stages: submission of the tender and evaluation of the tender.

Success Rates: The success rates are not mentioned in the provided content.

Co-funding Requirement: The co-funding requirement is not explicitly mentioned.

Summary:

This opportunity is a call for tenders (ECDC/2025/OP/0002) issued by the European Centre for Disease Prevention and Control (ECDC) for "Vaccine effectiveness, burden and impact studies". The tender is divided into two lots. Lot 1 focuses on vaccine effectiveness, disease burden, and impact studies using primary data in hospital and primary care settings, with an estimated value of 20,000,000 EUR. This lot includes work areas such as studies in the hospital setting, primary care setting, and additional ad hoc studies, potentially including zoonotic influenza. Lot 2 concentrates on similar studies but using mainly Electronic Health Registries, with an estimated value of 9,500,000 EUR. The total estimated value for both lots is 29,500,000 EUR.

The procedure type is an open procedure, and submissions must be made electronically. The maximum contract duration is 48 months, and the award method is based on the best price-quality ratio. The TED publication date was 30/10/2025, and the deadline for receipt of tenders is 16/12/2025 at 16:00 Europe/Stockholm. The contracting authority will not reply to questions submitted after 08/12/2025 07:00 Europe/Stockholm.

Eligible applicants can be either single entities or consortia, and they must register for a PIC (Personal Identification Code). The tender targets organizations with expertise in health services, particularly those with experience in conducting vaccine effectiveness studies and analyzing disease burden. The selected tenderers will enter into a framework agreement with the ECDC to provide these services. The eSubmission system supports multiple EU languages and accepts attachments up to 50 MB, with a maximum of 200 files per tender.