Advancing interdisciplinary, data-driven research at the biodiversity- health interface under a One Health approach

Overview

Horizon Europe Research and Innovation Action HORIZON-NATURE funds interdisciplinary, data-driven One Health research to advance FAIR data, interoperable infrastructures, analytical tools and a proof-of-concept linking biodiversity and human health. The topic has an indicative budget of €20,000,000, is single-stage, opens 3 June 2027 and closes 16 September 2027 at 17:00 Brussels time, and expects to fund one grant. Consortia must include at least seven independent legal entities established in seven different countries and deliver a minimum of six complementary use cases covering terrestrial, freshwater and marine ecosystems and key drivers of biodiversity loss. Proposals must address data sharing and interoperability, harmonised ontologies and reporting standards, validated analytical/data integration tools (including AI where appropriate), and policy- and practitioner-ready decision-support outputs.

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Highlights

Call at a glance

What the call funds

Horizon Europe Research and Innovation Action supporting interdisciplinary, FAIR-aligned data mobilisation, interoperability and analytical tools to operationalise One Health and Planetary Health. Activities must develop at least six thematic use cases (covering key drivers of biodiversity loss across at least three ecosystem types), enhance cross-domain data sharing and deliver a proof-of-concept for integrated One Health decision-support outputs for policy uptake.

Budget and deadlines:Single-stage call opening 03 June 2027; deadline 16 September 2027 (17:00 Brussels time). Indicative total contribution for the topic around €20,000,000 with one grant expected; applicants may request different amounts. 1

  1. 1Eligible applicants: consortia of independent legal entities across eligible Member States and Associated Countries (see Work Programme Annex B for full list).
  2. 2Consortium requirement: minimum seven beneficiaries, each established in a different country; at least one in an EU Member State plus six others in Member States or Associated Countries.
  3. 3Type of action: HORIZON Research and Innovation Actions (RIA) under Horizon Europe.
  4. 4Application page limit: 70 pages (application form and layout rules in Submission System).
  5. 5Evaluation thresholds: minimum 4 for Excellence, Impact and Implementation (cumulative 12).
Planned opening03 June 2027
Deadline (single-stage)16 September 2027, 17:00 Brussels time
Indicative EU contributionaround €20,000,000 (topic total); expected 1 grant

Consortia are expected to be multi-actor and interdisciplinary (life sciences, environmental sciences, social sciences, data providers), to leverage EOSC and other Common European Data Spaces and relevant research infrastructures, to engage stakeholders early, and to cluster with other funded projects for joint activities and policy outreach.

Footnotes

  1. 1FAIR principles and guidance: go-fair.org

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Breakdown

Call summary and administrative facts

Call identifier HORIZON-NATURE. Call title Transformative change towards a nature-positive economy and society. Topic title Advancing interdisciplinary, data-driven research at the biodiversity-health interface under a One Health approach. Programme Horizon Europe. Type of action HORIZON Research and Innovation Actions (HORIZON-RIA). Type of MGA HORIZON Action Grant Budget-Based (HORIZON-AG). Single-stage submission. Planned opening date 03 June 2027. Submission deadline 16 September 2027 at 17:00 Brussels time. Expected EU contribution around €20,000,000. Indicative number of grants expected 1.

Page limit and submission:Proposal total page limit 70 pages. Proposal layout and exact part/page rules are described in Part B of the Application Form available in the Submission System and in Annex A and Annex E of the Horizon Europe Work Programme General Annexes 1.

Scope, objectives and expected outcomes

Overall objective:support development of inter- and transdisciplinary research and operationalisation of One Health and Planetary Health approaches through data-driven, FAIR data-enabled use cases, interoperable infrastructures, analytical tools and a full proof-of-concept demonstrating holistic, cross-domain integration that links biodiversity, ecosystem health, wildlife, animal husbandry, plant and human health.

  1. 1Expected outcomes: Provide public authorities, researchers and policymakers with robust knowledge foundations and analytical frameworks enabling inter- and transdisciplinary biodiversity-related research and collaboration, addressing interdependencies and strengthening One Health/Planetary Health operationalisation.
  2. 2Make FAIR data accessible for researchers, public authorities and global organisations via enhanced digital infrastructures, mobilising and interoperating existing datasets across domains relevant to ecosystem and wildlife health and drivers of biodiversity loss and their impacts on human and animal health.
  3. 3Deliver evidence-based, actionable outputs (recommendations, guidelines, interoperable indicators, decision-support tools) enabling stakeholders to assess health benefits and risks from ecosystem maintenance, restoration and multi-host disease prevention and to implement biodiversity mainstreaming in One Health/Planetary Health actions.

Proposals must deliver three interconnected components:(1) minimum six thematic use cases; (2) enhanced data sharing and interoperability across thematic domains and validated analytical/Data Source Integration tools; (3) a proof-of-concept that integrates results to demonstrate a holistic One Health approach and produces uptake-ready outputs for policymakers and practitioners.

Detailed scope and technical requirements

  1. 1Use cases: Minimum six complementary thematic use cases. Collectively the use cases must address the most significant drivers of biodiversity loss (land and sea use change, direct exploitation, climate change, pollution to air water and soil, invasive alien and proliferating species) and their health impacts. Health outcomes to cover infectious diseases (including wildlife-domesticated interface, multi-host pathogens and spillover), non-communicable diseases and mental health where relevant. Use cases must explicitly be grounded in biodiversity and ecosystem health, include a mandatory link to human health, cover at least three different ecosystem types across terrestrial, freshwater and marine realms and span different biogeographical regions. Consideration of large-scale disturbances or environmental emergencies is allowed where relevant.
  2. 2Data sharing and interoperability: Select and mobilise existing datasets across domains relevant to the use cases. New data collection only when crucial knowledge gaps are identified. Identify critical data gaps with attention to European data sovereignty. Embed FAIR principles and CARE principles where relevant. Promote inter- and transdisciplinary data sharing practices, collaboration with EOSC Federation and Common European Data Spaces, and make use of European research infrastructures and services where applicable.
  3. 3Analytical tools, ontologies and governance: Develop and validate analytical and Data Source Integration tools, including AI models when appropriate, build harmonised ontologies, reporting standards and interoperable indicators. Provide data and software governance recommendations and embed FAIR/CARE in governance.
  4. 4Proof of concept: Create a full integration across domains using results from use cases to demonstrate how One Health/Planetary Health approaches enhance resilience to biodiversity loss, ecosystem degradation, diseases/pests, pollution and climate change. Produce evidence-based, actionable outputs, guidelines, decision-support tools and recommendations targeted at policymakers, risk assessors and relevant public authorities.
  5. 5Multi-actor, stakeholder engagement and uptake: Apply a multi-actor approach including data providers, Social Sciences and Humanities, affected communities, food producers, healthcare and animal health professionals, civil society, private sector and international organisations. Seek early and structured stakeholder engagement and plan uptake pathways including with EU/national agencies and international One Health organisations.
  6. 6EOSC, Common European Data Spaces and research infrastructures: Projects are encouraged to leverage EOSC and other Common European Data Spaces for digital services and to connect to European research infrastructures (ESFRI), ensuring robust validated data, sustainability and interoperability. Capitalise on datasets and results from recent or ongoing EU-funded projects and research agendas.
  7. 7Cluster participation and joint activities: All funded projects under this topic will form a cluster and participate in common networking and joint activities (common dissemination and communication strategy; common Data Management Strategy and Common Policy Strategy including joint policy briefs; thematic workshops/trainings; cooperation with the EC Knowledge Centre for Biodiversity and its Science Service; and answering science-to-policy requests). A dedicated work package for cluster activities with sufficient budget is required.

Mandatory scientific and technical emphases:Inter- and transdisciplinary integration across Life Sciences and Environmental domains; use and mobilisation of existing datasets; FAIR data implementation; development of interoperable ontologies and reporting standards; validated analytical integration tools (AI permitted where appropriate); proof-of-concept demonstrating operational One Health integration across domains.

Proposals are expected to support EU policy objectives including the EU Biodiversity Strategy for 2030, Nature Restoration Regulation, European Data Union Strategy, Strategy for European Life Sciences, EU Global Health Strategy, Kunming-Montreal Global Biodiversity Framework, EU One Health Approach and the global One Health agenda. Applicants are encouraged to reference and build on relevant projects and agendas cited in the topic text, and may indicate potential collaboration with the European Commission Joint Research Centre (JRC) which may join funded consortia without EU funding after evaluation.

Eligibility and consortium requirements

Eligibility rules follow Horizon Europe General Annexes. Additional specific eligibility for this topic:

  1. 1Consortium composition: At least seven independent legal entities established in seven different countries. At least one beneficiary must be established in an EU Member State and the other six in different Member States or Associated Countries.
  2. 2Decentralised EU agencies: ECDC and/or EFSA and/or EEA and/or other relevant decentralised EU agencies may participate as members of the consortium selected for funding. Agencies will not participate in proposal preparation or submission. Applicants may describe the envisaged contribution. If agreed after evaluation the agencies may join the grant agreement without funding.
  3. 3JRC participation: The Joint Research Centre may participate as a beneficiary with zero funding or as an associated partner. The JRC will not participate in proposal preparation or submission and any collaboration would be established post-selection.
  4. 4Copernicus / Galileo / EGNOS requirement: If projects use satellite-based Earth observation, positioning, navigation and/or related timing data/services, beneficiaries must make use of Copernicus and/or Galileo/EGNOS (additional services may be used).
  5. 5Eligible countries: As per Annex B of the Work Programme General Annexes. Non-EU/non-Associated countries may have national funding arrangements; consult the Horizon Europe Programme Guide.

Evaluation, scoring, thresholds and timeline

Evaluation follows Horizon Europe evaluation rules and the standard evaluation form for HE RIA with necessary adaptations. Scoring thresholds: Excellence 4; Impact 4; Implementation 4. Cumulative threshold 12. Detailed award criteria, scoring, admissibility, exclusion, financial and operational capacity and other procedural rules are in General Annexes (Annex C, D, F, G). Indicative evaluation timeline and grant agreement timeline described in Annex F and the Online Manual.

Evaluation criteriaThreshold
Excellence4
Impact4
Implementation4 (cumulative 12)

Financial and contractual model

Type of financial support:grant (budget-based HORIZON-AG). Expected EU contribution around €20,000,000 for one project (topic budget around €20,000,000 in 2027). Grants use Horizon Europe rules and the Horizon MGA (Model Grant Agreement) budget-based. Legal and financial set-up follows General Annex G. The granting authority may object up to four years after end of action to transfer of ownership or exclusive licensing of results as set out in Annex 5.

Co-funding and eligible costs:Co-funding: The action is funded under Horizon Europe; usual eligibility of costs, co-funding rules and rules on other sources of funding and cumulation apply as described in the Horizon Europe MGA and General Annexes. Applicants must demonstrate financial and operational capacity; exclusions and financial capacity checks follow Annex C.

Who should apply and eligible applicant types

Eligible applicant types:consortia of legal entities including but not limited to universities, research institutes, public research organisations, SMEs, large enterprises, NGOs, non-profit organisations, public authorities, hospitals, veterinary institutions, international organisations (subject to eligibility rules), and other societal partners. Participation of data providers, social sciences and humanities researchers, healthcare and animal health professionals, and private sector actors is encouraged. Legal entities from Member States and Horizon Europe Associated Countries are eligible as per Annex B. Individual natural persons cannot apply as beneficiaries; proposals are submitted by legal entities as part of a consortium.

Project maturity and expected activities

Expected project stage and TRL:Research and Innovation Action. Activities will range from research, development and validation of analytical and integration tools, data mobilisation, interoperability and ontology work, to demonstration/proof-of-concept of integrated One Health approaches. TRL is not specified as a strict numeric target in this topic; focus is on interdisciplinary research, data integration and operational proof-of-concept across domains. Projects should demonstrate pathways to policy and operational uptake.

Budget and number of grants

Indicative total budget for the topic:around €20,000,000 for 2027. Indicative number of grants: 1. Applicants may request different amounts but funding decisions depend on evaluation and available appropriations.

Application process, templates and forms

Submission method:single-stage open call. Use the Application Form in the Funding & Tenders Submission System. Proposal layout and page limits are specified in Part B of the Application Form. Use the standard evaluation form (HE RIA) with necessary adaptations. Reference documents and templates include: HE Programme Guide, HE Model Grant Agreement (HE MGA), Work Programme documents, General Annexes, Funding & Tenders Portal Online Manual and FAQ. Examples of standard application forms are available in the Submission System Reference Documents page.

Application form structure (guidance):Applicants must complete the online Application Form in the Submission System. Key parts: Part A administrative data and requested budget; Part B technical proposal including Excellence (objectives, methodology, use cases, FAIR data approach), Impact (policy relevance, uptake, dissemination, cluster participation, business/uptake plan where relevant), Implementation (consortium, management, work packages including cluster WP, data management plan, ethics, risk management, resources). Attachments: CVs, ethics self-assessment, Letter(s) of Commitment where appropriate, legal entity validation evidence, financial capacity documents if requested. Follow the Part B page layout rules.

Number of application stages and success rates

Application stages:Single-stage submission followed by independent evaluation against award criteria and possible clarification requests. After selection, the grant preparation and signature stage follows. Therefore applicants face effectively two main procedural stages: (1) proposal submission and peer evaluation; (2) grant preparation and signature. Success rates: not specified for this topic. Given one expected grant and an indicative budget of €20 million, success rate is likely low; actual success rate will depend on number and quality of proposals submitted.

Nature of support and allowed activities

Nature of support:Monetary grant funding (budget-based) plus non-monetary expected deliverables such as access to EOSC services, research infrastructures, datasets, standards and policy engagement. Beneficiaries receive money (grant) to perform project activities; projects are expected to produce digital services, open interoperable datasets where appropriate, tools and governance recommendations.

Cross-cutting priorities and encouraged elements

  1. 1Cross-cutting priorities: OCEAN, Social Sciences and Humanities (SSH), EOSC and FAIR data, Artificial Intelligence (AI), Digital Agenda, International Cooperation (INCO).
  2. 2Encouraged elements: multi-actor approach, involvement of Social Sciences and Humanities, international cooperation and participation of outermost regions, capitalising on EU-funded projects, use of EOSC and Common European Data Spaces, engagement with EC Knowledge Centre for Biodiversity and JRC, cluster participation and joint activities with other projects.

Technology and data specifics

Data:Proposals must mobilise and integrate existing datasets across biodiversity, ecosystem, wildlife, animal health, plant health, human health, environmental drivers and socio-economic domains. New data only if essential. Data must be FAIR (Findable, Accessible, Interoperable, Reusable) and CARE principles considered where relevant. Projects should build harmonised ontologies, reporting standards, interoperable indicators and Data Source Integration tools. Where AI is used, projects must ensure validation, governance, transparency and alignment with EOSC and relevant EU strategies.

Analytical tools and AI:Projects are expected to develop and validate analytical integration tools, including AI/ML models when appropriate, but must ensure robust governance, reproducibility, standards, and interoperability across domains and datasets. Tools should be validated within use cases and usable by stakeholders (policy, public authorities, risk assessors).

Relevant links and references

Applicants should consult the Funding & Tenders Portal topic page, General Annexes, the Horizon Europe Programme Guide, the Online Manual and the Model Grant Agreement. The call text references policy and infrastructure resources such as the EU Biodiversity Strategy for 2030, Nature Restoration Regulation, European Data Union Strategy, Strategy for European Life Sciences, EU Global Health Strategy, Kunming-Montreal Global Biodiversity Framework, EOSC Federation and ESFRI research infrastructures.

Mentioned countries / geographic scope:Beneficiary scope: EU Member States and Horizon Europe Associated Countries as described in Annex B of the Work Programme General Annexes. International cooperation is encouraged; participation of non-associated third countries may be subject to national arrangements and funding restrictions. Outermost regions participation is encouraged.

Success factors and recommendations for applicants

  1. 1Design at least six complementary use cases covering the major drivers of biodiversity loss and at least three ecosystem types across realms.
  2. 2Mobilise and harmonise existing high-quality datasets; justify any new data collection and address European data sovereignty.
  3. 3Embed FAIR (and CARE where relevant) principles in data governance and management; plan EOSC/Common European Data Spaces integration.
  4. 4Develop validated analytical integration tools and harmonised ontologies; demonstrate interoperability and provide governance recommendations.
  5. 5Plan structured stakeholder engagement, uptake pathways and policy-ready outputs; include a dedicated WP and budget for cluster activities and joint actions.
  6. 6Ensure consortium meets minimum eligibility (seven independent legal entities in seven countries) and include relevant multidisciplinary expertise including SSH, data science, public health, veterinary and environmental science.
  7. 7Follow Horizon evaluation criteria closely: clearly articulate Excellence, Impact and Implementation with evidence, milestones, risk management and robust project management and ethics compliance.

Reference to FAIR data resources and guidance is important for proposal assessment and implementation 1.

Comprehensive summary

This Horizon Europe Research and Innovation Action topic seeks to fund a single large interdisciplinary project (indicative EU contribution around €20 million) that will advance data-driven, interoperable, FAIR-enabled research at the biodiversity-health interface under a One Health approach. Applicants must form a minimum seven-partner consortium spanning EU Member States and Associated Countries and deliver at least six thematic use cases covering major drivers of biodiversity loss across multiple ecosystem types and biogeographical regions. The project must mobilise and interoperably integrate existing datasets, develop analytical and data integration tools (including validated AI where appropriate), build harmonised ontologies and reporting standards, embed FAIR and CARE principles, and produce a proof-of-concept demonstrating full cross-domain One Health integration with policy- and practitioner-ready outputs. Proposals should leverage EOSC, Common European Data Spaces and European research infrastructures where relevant, apply a multi-actor approach with early stakeholder engagement, capitalise on existing EU research outputs and join a funded cluster to coordinate dissemination, data management and policy engagement. Evaluation follows Horizon Europe standard criteria (Excellence, Impact, Implementation) with thresholds at 4/4/4 and cumulative 12. Applicants must follow the Submission System Application Form structure, respect the 70-page limit, and consult the General Annexes, Programme Guide and Online Manual for detailed admissibility, eligibility, financial and contractual rules.

Footnotes

  1. 1FAIR principles and guidance: see FAIR principles overview and practical resources such as the FAIR Cookbook and OpenAIRE guides. Example resources: FAIR principles; FAIR Cookbook; OpenAIRE how to make your data FAIR.

Short Summary

Impact

Enable operational One Health and Planetary Health decision-making by producing FAIR, interoperable cross-domain datasets, validated analytical tools and a proof-of-concept that delivers policy-ready recommendations, interoperable indicators and decision-support for biodiversity conservation, restoration and health risk reduction.

Applicant

Teams with interdisciplinary capacity in ecology/environmental science, public and animal health, data science (FAIR data, data governance, ontologies, AI/ML), and experience in stakeholder engagement and policy translation.

Developments

Data-driven development and mobilisation of interoperable FAIR data infrastructures, harmonised ontologies and reporting standards, validated analytical/Data Source Integration tools (including AI where appropriate), and at least six thematic use cases culminating in an integrated One Health proof-of-concept across terrestrial, freshwater and marine ecosystems.

Applicant Type

Researchers.

Consortium

Consortia are required:at least seven independent legal entities established in seven different countries (minimum one in an EU Member State and six in different Member States or Horizon Europe Associated Countries).

Funding Amount

Indicative topic budget around €20,000,000 for the topic with one expected grant (€20,000,000 per project indicative).

Countries

EU Member States and Horizon Europe Associated Countries are explicitly relevant, with at least one beneficiary in an EU Member State and the remaining six in different Member States or Associated Countries.

Industry

Biodiversity and One Health / Planetary Health (environmental biodiversity policy and cross-domain health integration).

Additional Web Data

This is a Horizon Europe Research and Innovation Action under the call Transformative change towards a nature-positive economy and society. It is a single-stage topic that opens on 3 June 2027 and closes on 16 September 2027 at 17:00 Brussels time, with an indicative topic budget of €20,000,000 and one expected grant2310.

What the funding is about

The topic aims to strengthen interdisciplinary research at the biodiversity-health interface by building robust knowledge foundations, FAIR data, interoperable digital infrastructures, analytical tools, and evidence-based outputs that support One Health and Planetary Health approaches. It is designed to help public authorities, researchers, policymakers and global organisations work with high-quality cross-domain data and practical decision support for biodiversity conservation, restoration and health protection23.

Proposals must develop at least six complementary use cases that together address the main drivers of biodiversity loss, including land and sea use change, direct exploitation, climate change, pollution, and invasive alien species. Those use cases must keep a mandatory link to human health and should cover infectious disease and non-communicable health impacts, including mental health, while considering the wildlife-domesticated animal interface and multi-host pathogens where relevant23.

The call also expects work on data sharing and interoperability, harmonised ontologies, reporting standards, data and software governance, and a proof of concept showing how integrated One Health and biodiversity approaches can improve resilience to biodiversity loss, ecosystem degradation, diseases, pollution and climate change23.

Who can apply

The consortium must include at least seven independent legal entities established in seven different countries, with at least one entity in a Member State and at least six additional independent entities each established in different Member States or Associated Countries. Eligible countries follow the Horizon Europe general rules, and the topic page points applicants to the general annexes for the detailed country eligibility framework.

The topic also encourages a multi-actor consortium that includes data providers and Social Sciences and Humanities expertise, together with early and structured stakeholder engagement, international cooperation, and participation from outermost regions.

Key applicant conditions

The following organisations may participate under the topic conditions:ECDC, EFSA, EEA and other relevant decentralised EU agencies may join the selected consortium without funding after the award, if an agreement is reached. The Joint Research Centre may participate as a zero-funded beneficiary or as an associated partner. If satellite-based earth observation, positioning, navigation or timing data are used, beneficiaries must use Copernicus and/or Galileo/EGNOS.

Funding and procedural snapshot

ItemDetail
Call titleTransformative change towards a nature-positive economy and society
Topic identifierHORIZON-NATURE
Action typeHORIZON-RIA Research and Innovation Action
MGA typeHORIZON Action Grant Budget-Based
Submission modelSingle-stage
Planned opening date3 June 2027210
Deadline16 September 2027, 17:00 Brussels time210
Indicative topic budget€20,000,0002310
Expected number of grants12310
Application page limit70 pages
Evaluation thresholds4 for Excellence, 4 for Impact, 4 for Implementation, 12 overall
Minimum consortium size7 independent legal entities in 7 countries
Funding rateNot specified on the topic page
Project durationNot specified on the topic page

What applicants should plan for

  1. 1At least six use cases that collectively span terrestrial, freshwater and marine ecosystems and different biogeographical regions.
  2. 2A mandatory human health link, with coverage of infectious disease and non-communicable health outcomes.
  3. 3Reuse of existing datasets wherever possible, with new data collection only for crucial gaps.
  4. 4Analysis of data gaps and sovereignty issues, plus cross-domain data sharing across life sciences and environmental domains.
  5. 5Use of EOSC Federation and other Common European Data Spaces where appropriate.
  6. 6Analytical and data source integration tools, including AI where relevant, together with harmonised ontologies and reporting standards.
  7. 7FAIR governance and, where relevant, CARE principles.
  8. 8A proof of concept that turns the use cases into actionable recommendations, guidelines, interoperable indicators and decision-support tools.
  9. 9A dedicated work package for clustering, networking and joint activities with the other funded projects.
  10. 10Early engagement with policymakers, public authorities, international organisations and other stakeholders to support uptake.

Overall assessment

This is a high-value, policy-facing biodiversity and health call that will suit strong interdisciplinary consortia with expertise in ecology, veterinary science, public health, data science and policy translation. Proposals will be most competitive if they combine credible cross-domain data integration, strong stakeholder engagement, and a clear One Health proof of concept with practical outputs for public authorities23.

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