Microbiome for terrestrial livestock sustainability and health within a One Health approach
Overview
Eligible applicants include universities, research institutes, small and medium-sized enterprises (SMEs), large enterprises, and relevant industry stakeholders involved in livestock and agricultural research. The call encourages multi-disciplinary collaborations, indicating that consortium participation is likely required for effective project execution.
The project aims to address major challenges such as antimicrobial resistance (AMR), zoonotic disease transmission, and the overall sustainability of livestock systems through innovative microbiome solutions. Proposed activities include investigating the microbiome's effects on animal health, developing integrated data monitoring systems that assess health indicators across livestock and plant sectors, and creating models to enhance animal welfare while reducing antimicrobial usage.
The project is aligned with broader EU policies, including the EU Green Deal and the One Health Action Plan against AMR, and it demands a collaborative effort among various specialists like veterinarians, microbiologists, and ecologists. As part of its applied research focus, the projects will need to facilitate platforms for data sharing and knowledge exchange within a One Health context.
Proposals must meet specific conditions outlined in the Horizon Europe Work Programme, which emphasizes admissibility conditions, eligible countries, and financial requirements. The evaluation process will assess proposals based on their excellence, impact, and implementation quality.
In conclusion, this funding opportunity represents a substantial investment in advancing sustainable livestock practices and health through critical microbiome research, inviting advanced proposals from capable research teams with a collaborative spirit.
Detail
The expected outcomes of this call are: a better understanding of the role of the microbiome on livestock health and production and the interaction with environment and human health within a One Health approach among the research community, farmers, livestock industry (e.g., breeders, service providers, policymakers); access to a platform of tools for data sharing, knowledge exchange, capacity building and standardization in microbiome research and its applications through synergies with other platforms in a One Health context for researchers' communities and innovators in the livestock sector; and targeted strategies and guidelines available to farmers, service providers and livestock industry to contribute to improving livestock health, while reducing antimicrobial use and environmental impact, and securing animal welfare.
The scope of this call is to address the transformative potential of microbiome research for livestock management within the One Health (OH) framework. This framework emphasizes the interconnected health of animals, humans, and the environment. The call aims to address issues such as antimicrobial resistance (AMR) and zoonotic disease transmission in livestock. It also seeks to fill gaps in understanding host-microbiome interactions, sustainable farming practices, and the assessment of interventions in real-world settings. The objective is to support sustainable livestock systems that align with OH principles through microbiome-based solutions and cross-disciplinary collaboration.
Proposals should address the following activities:
1. Investigate the microbiome of terrestrial livestock, their influence on animal health, taking into account the holobiont/hologenome perspectives, and the interactions with the environment (soil, plant, water, air) and human health.
2. Develop integrated data monitoring systems that track microbiome related health indicators across livestock, plant, and human health sectors, and help in risk assessment models for zoonotic disease and/or AMR emergence and transmission.
3. Assess how microbiome-based solutions for animal health affect, and are affected by, soil and plant health, and the use of chemical fertilisers and pesticides.
4. Design holistic health models that incorporate microbiome research to enhance the robustness of animals as well as animal health and welfare, and overall productivity, taking into account soil and plant health, and to assess potential synergies and trade-offs between these objectives.
5. Design microbiome related intervention strategies to prevent outbreaks and cross-species transmission in animal populations and reduce the risk of zoonosis, thereby contributing to reduced antimicrobial usage while enhancing resilience, animal welfare, and minimizing environmental impact.
6. Develop, or contribute to, platforms to collaboratively assess and optimise the efficacy and implementation of microbiome-based tools, products and services in the livestock sector through synergies with other platforms within a One Health context.
7. Enhance collaboration among veterinarians, microbiologists, geneticists, animal and plant biologists, epidemiologists, and ecologists and other experts to work towards a One Health approach.
Projects selected under this topic should interact between themselves and build on/interact with recent or on-going EU funded projects and initiatives, including those funded under the topic HORIZON-CL6-2026-02-FARM2FORK-11: Integrating a holistic perspective in microbiome research for resilient, competitive and sustainable food systems, as well as with relevant activities of the European partnerships on animal health and welfare, on One health AMR, and on pandemic preparedness.
The projects under this topic are relevant to the EU policies related to the EU Green Deal’s goals for resilient and sustainable agri-food systems, the EU biodiversity strategy for 2030, the Life Sciences strategy, the Vision for Agriculture and Food, the EU One Health Action Plan against Antimicrobial Resistance, and the Council Recommendation on stepping up EU actions to combat antimicrobial resistance in a One Health approach.
General conditions for participation include:
1. Admissibility Conditions: Proposal page limit and layout described in Annex A and Annex E of the Horizon Europe Work Programme General Annexes and Part B of the Application Form.
2. Eligible Countries described in Annex B of the Work Programme General Annexes. Specific provisions may apply to non-EU/non-Associated Countries as detailed in the Horizon Europe Programme Guide.
3. Other Eligible Conditions described in Annex B of the Work Programme General Annexes.
4. Financial and operational capacity and exclusion described in Annex C of the Work Programme General Annexes.
5. Evaluation and award: Award criteria, scoring and thresholds described in Annex D of the Work Programme General Annexes. Submission and evaluation processes are described in Annex F of the Work Programme General Annexes and the Online Manual. The indicative timeline for evaluation and grant agreement is described in Annex F of the Work Programme General Annexes.
6. Legal and financial set-up of the grants: Eligible costs will take the form of a lump sum as defined in the Decision of 7 July 2021. This is further described in Annex G of the Work Programme General Annexes.
Specific conditions are described in the specific topic of the Work Programme.
Application and evaluation forms and model grant agreement (MGA) information:
* Application form templates are available in the Submission System, including the Standard application form (HE RIA, IA).
* Evaluation form templates will be used with necessary adaptations, including the Standard evaluation form (HE RIA, IA).
* Guidance is provided in the HE Programme Guide.
* Model Grant Agreements (MGA) include the Lump Sum MGA.
* Call-specific instructions include a detailed budget table (HE LS) and guidance on lump sums.
Additional documents include:
* HE Main Work Programme 2026-2027 – 1. General Introduction
* HE Main Work Programme 2026-2027 – 9. Food, Bioeconomy, Natural Resources, Agriculture and Environment
* HE Main Work Programme 2026-2027 – 15. General Annexes
* HE Programme Guide
* HE Framework Programme 2021/695
* HE Specific Programme Decision 2021/764
* EU Financial Regulation 2024/2509
* Decision authorising the use of lump sum contributions under the Horizon Europe Programme
* Rules for Legal Entity Validation, LEAR Appointment and Financial Capacity Assessment
* EU Grants AGA — Annotated Model Grant Agreement
* Funding & Tenders Portal Online Manual
* Funding & Tenders Portal Terms and Conditions
* Funding & Tenders Portal Privacy Statement
The budget overview for the HORIZON-CL6-2027-02 call includes several topics, each with a specific budget, opening date, deadline, and indicative number of grants. The HORIZON-CL6-2027-02-FARM2FORK-03 topic has a budget of 11,800,000 EUR and aims to award 2 grants, each ranging from 5,000,000 to 6,000,000 EUR. The opening date is April 20, 2027, and the deadline is September 23, 2027.
Partner search announcements are available for those seeking collaboration. LEARs, Account Administrators, and self-registrants can publish partner requests.
The submission system is planned to open on the date stated in the topic header.
Additional support and information can be found in the Online Manual, Horizon Europe Programme Guide, Funding & Tenders Portal FAQ, Research Enquiry Service, National Contact Points (NCPs), Enterprise Europe Network, IT Helpdesk, European IPR Helpdesk, CEN-CENELEC Research Helpdesk, ETSI Research Helpdesk, and the European Charter for Researchers.
In summary, this Horizon Europe call seeks to fund research and innovation actions that explore the potential of microbiome research to improve the sustainability and health of terrestrial livestock within a One Health framework. It encourages interdisciplinary collaboration and the development of practical solutions to address challenges such as antimicrobial resistance and zoonotic disease transmission. The call provides a lump sum grant and has a single-stage submission process with a deadline in September 2027. Successful projects are expected to contribute to a better understanding of the microbiome's role, provide tools for data sharing and standardization, and develop targeted strategies for improving livestock health and welfare while reducing environmental impact.
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Breakdown
Funding Type: The primary financial mechanism is a grant, specifically a HORIZON Lump Sum Grant. The call includes HORIZON Research and Innovation Actions (HORIZON-RIA), HORIZON Innovation Actions (HORIZON-IA) and HORIZON Coordination and Support Actions (HORIZON-CSA).
Consortium Requirement: The opportunity does not explicitly state whether a single applicant or a consortium is required. However, given the scope and nature of the activities, particularly the need for cross-disciplinary collaboration, it is highly likely that a consortium of multiple applicants is expected. Partner Search tools are available to help applicants form consortia.
Beneficiary Scope (Geographic Eligibility): The primary geographic eligibility includes EU member states and countries associated with the Horizon Europe program. The opportunity mentions that a number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide.
Target Sector: The program targets the following sectors: agriculture, food, bioeconomy, natural resources, environment, climate, and health. Specifically, it focuses on microbiome research for terrestrial livestock sustainability and health within a One Health approach, addressing issues like antimicrobial resistance (AMR), zoonotic disease transmission, and sustainable farming practices.
Mentioned Countries: The opportunity explicitly mentions EU member states and associated countries. It also refers to non-EU/non-associated countries that may have specific provisions for funding.
Project Stage: The project stage varies depending on the type of action. Research and Innovation Actions (RIA) typically support projects from research to development and validation. Innovation Actions (IA) focus on demonstration, piloting, and market uptake. Coordination and Support Actions (CSA) support networking, coordination, and dissemination activities. The projects are expected to advance from research to practical applications and implementation in real-world farming settings.
Funding Amount: The funding amounts vary by topic:
HORIZON-CL6-2027-02-CLIMATE-01: EUR 16,000,000 (Indicative grant: around EUR 8,000,000)
HORIZON-CL6-2027-02-CLIMATE-02: EUR 12,000,000 (Indicative grant: around EUR 6,000,000)
HORIZON-CL6-2027-02-CLIMATE-03: EUR 12,000,000 (Indicative grant: around EUR 6,000,000)
HORIZON-CL6-2027-02-CLIMATE-04: EUR 22,000,000 (Indicative grant: around EUR 11,000,000)
HORIZON-CL6-2027-02-COMMUNITIES-01: EUR 15,000,000 (Indicative grant: around EUR 5,000,000)
HORIZON-CL6-2027-02-COMMUNITIES-02: EUR 12,000,000 (Indicative grant: around EUR 6,000,000)
HORIZON-CL6-2027-02-FARM2FORK-01: EUR 12,000,000 (Indicative grant: around EUR 6,000,000)
HORIZON-CL6-2027-02-FARM2FORK-02: EUR 12,000,000 (Indicative grant: around EUR 6,000,000)
HORIZON-CL6-2027-02-FARM2FORK-03: EUR 11,800,000 (Indicative grant: EUR 5,000,000 to EUR 6,000,000)
HORIZON-CL6-2027-02-FARM2FORK-04: EUR 6,000,000 (Indicative grant: around EUR 6,000,000)
HORIZON-CL6-2027-02-FARM2FORK-05: EUR 12,000,000 (Indicative grant: around EUR 6,000,000)
HORIZON-CL6-2027-02-FARM2FORK-06: EUR 10,000,000 (Indicative grant: around EUR 5,000,000)
HORIZON-CL6-2027-02-FARM2FORK-07: EUR 15,500,000 (Indicative grant: EUR 7,000,000 to EUR 8,000,000)
HORIZON-CL6-2027-02-FARM2FORK-08: EUR 7,800,000 (Indicative grant: around EUR 7,800,000)
HORIZON-CL6-2027-02-FARM2FORK-09: EUR 6,750,000 (Indicative grant: around EUR 6,750,000)
Application Type: The application type is an open call with a single-stage submission process.
Nature of Support: Beneficiaries will receive funding in the form of a lump sum grant.
Application Stages: The application process involves a single stage.
Success Rates: The success rates are not explicitly mentioned, but the indicative number of grants for each topic provides some insight. For example, HORIZON-CL6-2027-02-FARM2FORK-03 indicates that two grants will be awarded for a total budget of EUR 11,800,000.
Co-funding Requirement: The need for co-funding is not explicitly mentioned. However, Horizon Europe grants often encourage or require some level of co-funding, which would be detailed in the specific call documents.
Summary: This Horizon Europe call, part of the HORIZON-CL6-2027-02 program, focuses on "Microbiome for terrestrial livestock sustainability and health within a One Health approach." It aims to leverage microbiome research to improve livestock management, address antimicrobial resistance, and promote sustainable farming practices. The call invites proposals for Research and Innovation Actions (RIA), Innovation Actions (IA), and Coordination and Support Actions (CSA). Eligible applicants include a wide range of entities such as research organizations, universities, SMEs, and industry stakeholders from EU member states, associated countries, and potentially other countries. The funding is provided as lump sum grants, with varying budgets depending on the specific topic. Projects should foster cross-disciplinary collaboration and contribute to EU Green Deal objectives, the EU biodiversity strategy, and the One Health Action Plan against Antimicrobial Resistance. The application process is a single-stage submission, with a planned opening date of April 20, 2027, and a deadline of September 23, 2027. The call seeks to enhance the understanding of the microbiome's role in livestock health and production, develop data monitoring systems, assess microbiome-based solutions, design holistic health models, and create intervention strategies to prevent disease outbreaks and reduce antimicrobial usage.
Short Summary
Impact The funding aims to enhance the sustainability and health of terrestrial livestock through microbiome research within a One Health approach, addressing issues like antimicrobial resistance and zoonotic disease transmission. | Impact | The funding aims to enhance the sustainability and health of terrestrial livestock through microbiome research within a One Health approach, addressing issues like antimicrobial resistance and zoonotic disease transmission. |
Applicant Applicants should possess expertise in microbiome research, veterinary sciences, animal health, and interdisciplinary collaboration among various scientific fields. | Applicant | Applicants should possess expertise in microbiome research, veterinary sciences, animal health, and interdisciplinary collaboration among various scientific fields. |
Developments The funding will support research projects focused on microbiome applications in livestock management, integrating animal, human, and environmental health. | Developments | The funding will support research projects focused on microbiome applications in livestock management, integrating animal, human, and environmental health. |
Applicant Type This funding is designed for universities, research institutes, SMEs, large enterprises, and industry stakeholders involved in agricultural research and innovation. | Applicant Type | This funding is designed for universities, research institutes, SMEs, large enterprises, and industry stakeholders involved in agricultural research and innovation. |
Consortium A consortium of multiple applicants is strongly encouraged to foster cross-disciplinary collaboration. | Consortium | A consortium of multiple applicants is strongly encouraged to foster cross-disciplinary collaboration. |
Funding Amount Funding amounts range from €5,000,000 to €6,000,000 per project, with a total budget of €11,800,000 for the topic. | Funding Amount | Funding amounts range from €5,000,000 to €6,000,000 per project, with a total budget of €11,800,000 for the topic. |
Countries Eligible countries include EU Member States and EEA countries, with potential provisions for certain non-EU/non-associated countries. | Countries | Eligible countries include EU Member States and EEA countries, with potential provisions for certain non-EU/non-associated countries. |
Industry The funding targets the agriculture, bioeconomy, and health sectors, specifically focusing on sustainable livestock systems and microbiome research. | Industry | The funding targets the agriculture, bioeconomy, and health sectors, specifically focusing on sustainable livestock systems and microbiome research. |
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