Leveraging R&I knowledge on microbiome

Overview

The funding opportunity HORIZON-CL6-2026-02-FARM2FORK-12 falls under the Horizon Europe program, specifically offering a lump sum grant as part of a Coordination and Support Action (CSA). This opportunity is designed to enhance research and innovation (R&I) efforts related to microbiome science, focusing on creating a centralized hub for knowledge and resources for various stakeholders, including researchers, policymakers, and regulators.

Eligible applicants include universities, research organizations, public and private entities, and non-profit organizations. A consortium of multiple entities is required to effectively coordinate and integrate efforts among EU member states and associated countries. The geographical eligibility spans EU and EEA member states, with potential provisions available for certain non-EU countries.

The target sectors encompass agriculture, health, climate, biodiversity, and food systems, and emphasize a One Health perspective that links human, animal, and environmental health. The project aims to address fragmentation in microbiome research, focusing on enhancing the connection between existing initiatives and informing policy development.

Funding for this CSA amounts to €2,000,000, with a single-stage submission process where applicants must submit their proposals by April 14, 2026. The primary goal is to establish a comprehensive resource center that maps the microbiome research landscape, identifies synergies and gaps, and develops guidance for policy frameworks influenced by microbiome science.

No mandatory co-funding is required, though collaborations with co-funding entities could enhance proposal competitiveness. Additionally, the opportunity aligns with broader EU policies, including the Farm to Fork Strategy and the EU Biodiversity Strategy, while focusing on developing evidence-based recommendations to drive future research and innovation efforts in microbiome studies.

In summary, this funding opportunity represents a strategic investment in harmonizing microbiome research across Europe and fostering an integrative approach to environmental and health issues related to microbiome applications.

Detail

This is a description of the EU funding opportunity HORIZON-CL6-2026-02-FARM2FORK-12, which falls under the Horizon Europe (HORIZON) program, specifically Call 02 single stage (2026) (HORIZON-CL6-2026-02). The type of action is a HORIZON Coordination and Support Action (HORIZON-CSA) with a HORIZON Lump Sum Grant [HORIZON-AG-LS] model grant agreement. This is a forthcoming opportunity with a single-stage deadline model. The planned opening date is 14 January 2026, and the deadline for submission is 14 April 2026 at 17:00:00 Brussels time.

The expected outcomes of this funding opportunity are to:

Provide a microbiome one-stop-shop containing resources and knowledge (information on microbiome R&I landscape, databases, best practices, risk assessments and food safety, aspects related to the environment and biodiversity, policy briefs…) for stakeholders involved in microbiome R&I (researchers, policymakers, and regulators).

Offer guidance for policymakers, focusing on the integrated link between the microbiome and its interconnection with human health, climate, environment, agriculture, and food systems, emphasizing the One Health perspective.

Enhance integration and coordination between member states and associated countries on microbiome research and innovation within a One Health context, encompassing all kinds of microbiomes.

The scope of this funding opportunity focuses on microbiome research, which has gained traction recently but remains fragmented. There is a need for a coordination body that monitors research in this sector and steers research efforts in a strategic direction. Regulatory requirements remain one of the biggest challenges in translating microbiome research into innovative solutions, and such a body would ensure the continuity of regulatory harmonization efforts conducted by previous and existing initiatives.

The topic is relevant to EU policies related to the Commission communication on Building the future with nature: Boosting Biotechnology and Biomanufacturing in the EU, the EU life science strategy, the EU biodiversity strategy for 2030, the zero pollution action plan, the EU strategy on research and technology infrastructure, the R&I food 2030 framework, and the digital transition policies (e.g., AI Act, etc.).

Proposals should address the following activities:

Establishment of a hub acting as a resource center and a monitoring body of the microbiome R&I and regulatory landscape.

Fostering and strengthening synergies between existing coordination efforts and national initiatives in alignment with EU microbiome initiatives.

Mapping of all ongoing and past EU-based microbiome projects, EU research and technology infrastructures, and EU initiatives (public and private).

Identifying overlaps, synergies, and gaps across all microbiome domains, notably to inform future funding and policy directions.

Collaborating with relevant ongoing initiatives (e.g., the World Microbiome Partnership), EU-funded projects (e.g., HORIZON-CL6-2026-02-FARM2FORK-11), and building on outcomes of legacy EU microbiome projects, among others, to ensure coordinated action, avoid duplication of efforts, build on existing achievements, and foster financial synergies by identifying microbiome R&I funding gaps.

Monitoring and assessing the microbiome R&I impact on the population, the environment, biodiversity, the EU economy, and competitiveness through specific indicators targeting EU and national policies priorities with an emphasis on One Health principles and across all microbiome types.

The general conditions for this funding opportunity include:

Admissibility Conditions: Proposal page limit and layout described in Annex A and Annex E of the Horizon Europe Work Programme General Annexes. Proposal page limits and layout are described in Part B of the Application Form available in the Submission System.

Eligible Countries described in Annex B of the Work Programme General Annexes. A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide.

Other Eligible Conditions described in Annex B of the Work Programme General Annexes.

Financial and operational capacity and exclusion described in Annex C of the Work Programme General Annexes.

Evaluation and award: Award criteria, scoring, and thresholds are described in Annex D of the Work Programme General Annexes.

Evaluation and award: Submission and evaluation processes are described in Annex F of the Work Programme General Annexes and the Online Manual.

Evaluation and award: Indicative timeline for evaluation and grant agreement described in Annex F of the Work Programme General Annexes.

Legal and financial set-up of the grants: Eligible costs will take the form of a lump sum as defined in the Decision of 7 July 2021 authorizing the use of lump sum contributions under the Horizon Europe Programme – the Framework Programme for Research and Innovation (2021-2027) – and in actions under the Research and Training Programme of the European Atomic Energy Community (2021-2025). This decision is available on the Funding and Tenders Portal, in the reference documents section for Horizon Europe, under ‘Simplified costs decisions’.

Annex G of the Work Programme General Annexes provides additional information.

Specific conditions are described in the specific topic of the Work Programme.

Application and evaluation forms and model grant agreement (MGA) information:

Application form templates: The application form specific to this call is available in the Submission System. The standard application form is HE CSA.

Evaluation form templates: These will be used with the necessary adaptations. The standard evaluation form is HE CSA.

Guidance: The HE Programme Guide provides guidance.

Model Grant Agreements (MGA): The Lump Sum MGA is applicable.

Call-specific instructions: A detailed budget table (HE LS) and guidance on "Lump sums - what do I need to know?" are available.

Additional documents include:

HE Main Work Programme 2026-2027 – 1. General Introduction

HE Main Work Programme 2026-2027 – 9. Food, Bioeconomy, Natural Resources, Agriculture and Environment

HE Main Work Programme 2026-2027 – 15. General Annexes

HE Programme Guide

HE Framework Programme 2021/695

HE Specific Programme Decision 2021/764

EU Financial Regulation 2024/2509

Decision authorizing the use of lump sum contributions under the Horizon Europe Programme

Rules for Legal Entity Validation, LEAR Appointment, and Financial Capacity Assessment

EU Grants AGA — Annotated Model Grant Agreement

Funding & Tenders Portal Online Manual

Funding & Tenders Portal Terms and Conditions

Funding & Tenders Portal Privacy Statement

The budget overview for this topic and related topics in the HORIZON-CL6-2026-02 call includes various actions with their respective budgets, opening dates, deadlines, contributions, and indicative number of grants.

Partner search announcements are available for finding collaborators on this topic. LEARs, Account Administrators, or self-registrants can publish partner requests for open and forthcoming topics after logging into the Portal, as well as any user having an active public Person profile.

The submission system is planned to be opened on the date stated on the topic header.

General support information is provided, including links to the Online Manual, Horizon Europe Programme Guide, Funding & Tenders Portal FAQ, Research Enquiry Service, National Contact Points (NCPs), Enterprise Europe Network, IT Helpdesk, European IPR Helpdesk, CEN-CENELEC Research Helpdesk, ETSI Research Helpdesk, and the European Charter for Researchers and the Code of Conduct for their recruitment.

In summary, this funding opportunity aims to establish a comprehensive resource and coordination hub for microbiome research and innovation within the EU. It seeks to address the fragmented nature of current research efforts, promote synergies between existing initiatives, and provide guidance to policymakers on the integrated links between microbiomes and various sectors, including health, climate, environment, agriculture, and food systems. The funding is provided as a lump sum, and the call is a single-stage process with a deadline in April 2026. The initiative encourages collaboration and coordination to maximize the impact of microbiome R&I across Europe.

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Breakdown

Eligible Applicant Types: The eligible applicant types are not explicitly stated in the provided text. However, given the nature of Horizon Europe Coordination and Support Actions (CSA) and Research and Innovation Actions (RIA) and Innovation Actions (IA), eligible applicants typically include universities, research institutes, SMEs, large enterprises, and other organizations capable of conducting research and innovation activities. The mention of "LEARs, Account Administrators or self-registrants" suggests that registered legal entities are eligible.

Funding Type: The primary financial mechanism is a grant, specifically a HORIZON Lump Sum Grant. The call also includes HORIZON Research and Innovation Actions (RIA), HORIZON Innovation Actions (IA) and HORIZON Coordination and Support Actions (CSA).

Consortium Requirement: The text does not explicitly state whether a consortium is required. However, the encouragement of partner searches and the nature of the activities suggest that consortia are likely preferred, although single applicants might be eligible depending on the specific topic requirements.

Beneficiary Scope (Geographic Eligibility): The primary geographic eligibility appears to be EU member states and associated countries. The text mentions that "A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects," indicating that some third-country participation is possible.

Target Sector: The program targets the following sectors: microbiome research, biotechnology, biomanufacturing, life sciences, biodiversity, environment, agriculture, food systems, climate, and digital technologies (AI). It is strongly oriented towards the "One Health" perspective, linking human health, animal health, and environmental health.

Mentioned Countries: The text refers to EU member states and associated countries, as well as "non-EU/non-Associated Countries" (third countries) that have specific funding provisions.

Project Stage: The project stages targeted vary depending on the specific action type:
Research and Innovation Actions (RIA): Focus on research and development activities.
Innovation Actions (IA): Focus on demonstration, piloting, and validation activities, closer to market.
Coordination and Support Actions (CSA): Focus on networking, coordination, and dissemination activities.
Overall, the projects range from research to innovation and coordination.

Funding Amount: The funding amounts vary depending on the specific topic:
Under €50k: No explicit mention.
€50k–€200k: No explicit mention.
€200k–€1M: No explicit mention.
€1M–€5M: Several FARM2FORK and CLIMATE topics fall within this range.
Over €5M: Several FARM2FORK, CLIMATE and COMMUNITIES topics fall within this range, some reaching €14M.
Variable: Yes, the funding varies significantly by topic.

Application Type: The application type is an open call, with a single-stage submission process.

Nature of Support: Beneficiaries will receive money in the form of a lump sum grant to cover eligible costs.

Application Stages: The application process is single-stage.

Success Rates: The success rates are not explicitly mentioned.

Co-funding Requirement: The text does not explicitly mention a co-funding requirement.

Summary: This opportunity is a call for proposals under the Horizon Europe program, specifically targeting actions related to microbiome research, climate, food systems ("Farm to Fork"), and communities. It aims to foster research, innovation, coordination, and support activities related to these areas. The call is structured around different types of actions, including Research and Innovation Actions (RIA), Innovation Actions (IA), and Coordination and Support Actions (CSA), each with specific objectives and funding levels. The geographic focus is primarily on EU member states and associated countries, with some possibilities for third-country participation. The funding is provided as lump sum grants, and the application process is single-stage. The call emphasizes a "One Health" approach, linking human, animal, and environmental health, and seeks to address fragmentation in microbiome research while promoting regulatory harmonization and policy development.

Short Summary

Impact
Establish a comprehensive resource and coordination hub for microbiome research and innovation within the EU, addressing fragmentation and promoting synergies between existing initiatives while providing guidance to policymakers.
Applicant
Applicants should possess strong institutional capacity and experience in coordinating complex multi-stakeholder networks, particularly in microbiome research and regulatory science.
Developments
Funding will support activities related to microbiome research, including establishing a hub for knowledge consolidation, mapping ongoing projects, and developing policy guidance.
Applicant Type
This funding is designed for research organizations, universities, research institutes, public bodies, private enterprises, and non-profit organizations.
Consortium
A consortium of multiple applicants is required for this opportunity.
Funding Amount
The funding amount for this specific topic is a fixed lump sum of €2,000,000.
Countries
The opportunity is eligible for applicants from EU and EEA member states and associated countries, with some provisions for third-country participation.
Industry
This funding targets multiple interconnected sectors including agriculture, food systems, health, and environmental sustainability, aligning with the EU Farm to Fork Strategy and other related policies.

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