Implementing digital services to empower neuroscience research for health and brain inspired technology via EBRAINS

Overview

The Horizon Europe call titled HORIZON-INFRA-2026-SERV-01-01 focuses on implementing digital services to empower neuroscience research for health and brain-inspired technologies through the EBRAINS initiative. With a substantial budget of €32 million, this call is aimed at enhancing and operating the EBRAINS research infrastructure. It invites applications from a variety of eligible entities including research institutions, universities, SMEs, large enterprises, and public-private partnerships, emphasizing the need for a robust consortium capable of collaborating on the project's complex requirements.

The funding type is grant-based, structured under the HORIZON Research and Innovation Actions framework, specifically designed to support operational and developmental aspects related to the EBRAINS infrastructure. Applications must be submitted in a single stage, with a deadline of June 16, 2026, after an opening date of March 10, 2026. The project seeks to promote effective research and innovation activities across neuroscience and health sciences, particularly emphasizing advanced computing and AI applications.

Geographically, eligibility spans EU member states and associated countries, with special provisions allowing participation from non-EU nations under specific arrangements. The call targets several interconnected sectors, including neuroscience, brain medicine, artificial intelligence, and digital health technologies.

Project proposals should demonstrate scalability and robustness, integrating AI tools for enhanced data analysis and user interaction while ensuring compliance with FAIR data principles. Successful applicants will not only receive financial support but may also access substantial non-monetary resources, including technical support, computational capacity, and collaborative platforms for knowledge sharing.

The expected outcomes of this initiative include establishing a state-of-the-art EBRAINS infrastructure, developing innovative AI tools, and fostering collaborative international brain health research. The opportunity aims to strengthen Europe's role in digital neuroscience research while bridging basic and clinical research initiatives, ultimately enhancing understanding of the human brain and improving patient care. Proposals should align with broader European health strategies and emphasize collaboration with existing research infrastructures to maximize impact.

Detail

This is a summary of a Horizon Europe call for proposals focusing on implementing digital services to empower neuroscience research for health and brain-inspired technology via EBRAINS. The call, titled HORIZON-INFRA-2026-SERV-01-01, falls under the Research Infrastructures 2026 (HORIZON-INFRA-2026-01) call within the Horizon Europe (HORIZON) program. It aims to support the excellence and attractiveness of the EBRAINS Research Infrastructure by operating existing, improved, and new services, advancing scientific and technological discoveries in neurosciences, brain medicine, and brain-inspired cognitive technologies, and attracting a wide community of users, including industrial users.

The expected outcomes of this call include:

A state-of-the-art EBRAINS digital infrastructure for brain research, providing data, digital tools, and services to the European research communities in neurosciences, brain medicine, and brain-inspired technologies. This platform will be AI-powered and will integrate innovative AI tools to support intuitive user interaction, facilitate brain research, data analysis, simulations, and brain modeling, and support FAIR data indexing and archival for scaled-up data integration and curation.

New services and applications for neuroscience, brain health, and cognitive technologies, aligned with national and European research priorities. The focus will be on workflows that connect and integrate large sets of data, services, and tools available at EBRAINS, combined with access to large storage and compute resources.

Innovative brain-inspired AI tools based on insights from brain research, such as learning, decision process, and plasticity, with applications in research, robotics, and neurotech.

Detailed, data-driven, multi-scale models of complex behavior, intelligence, consciousness, and language, to study the role of variability in human brain organization during the lifespan under different conditions.

Digital brain twins and/or body twins, informed by real-life sensor data, to assist in developing new digital tools for brain medicine, such as diagnostics, rehabilitation, intensive care, and surgery.

A framework for the European Brain Data Space, aligned with the European Health Data Space, connected to EOSC, and linked with common European data spaces in the life science and health sector, to support collaborative digital neuroscience and reproducible brain science, and to bridge basic and clinical research within the European partnership for brain health.

Strengthened European cooperation advancing brain health research to ensure streamlined efforts, avoid duplication while maximizing impact particularly in the context of the European Partnership for Brain Health through shared infrastructure, leading to improved diagnostics, innovative therapies, and more personalized treatment plans, ultimately enhancing patient care and public health.

The scope of the call includes operating EBRAINS research infrastructure digital facilities, supporting the use of EBRAINS digital services by researchers, integrating AI tools in EBRAINS services, demonstrating scalability and robustness of approaches, developing and integrating a new collaborative platform for advancing and testing neuro-inspired AI, strengthening international collaborations, and developing tailored training and skills development programs.

Proposals should outline how they will contribute to and align with European efforts on health data sharing, particularly in the context of the forthcoming European Health Data Space, implementing FAIR data principles and mechanisms. They should also identify and build on synergies with other EU Research Infrastructures such as eBRAIN-Health, EUCAIM, Euro-BioImaging, TEF-Health, and other relevant infrastructures supported under Horizon Europe or previous framework programmes.

The call is a HORIZON Research and Innovation Action (HORIZON-RIA) with a single-stage deadline model. The planned opening date is 10 March 2026, and the deadline for submission is 16 June 2026, at 17:00:00 Brussels time. The application page limit is 100 pages, as described in Annex A and Annex E of the Horizon Europe Work Programme General Annexes and Part B of the Application Form available in the Submission System.

Eligible countries are described in Annex B of the Work Programme General Annexes. A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects. See the information in the Horizon Europe Programme Guide. There are restrictions for the protection of European communication networks. Access provision activities must be included in the proposal.

Financial and operational capacity and exclusion are described in Annex C of the Work Programme General Annexes. Award criteria, scoring, and thresholds are described in Annex D of the Work Programme General Annexes. Submission and evaluation processes are described in Annex F of the Work Programme General Annexes and the Online Manual. The indicative timeline for evaluation and grant agreement is described in Annex F of the Work Programme General Annexes. Legal and financial set-up of the grants are described in Annex G of the Work Programme General Annexes. Eligible costs may take the form of unit costs for trans-national and virtual access to research infrastructures as defined in the Decision authorising the use of unit costs for the actions involving trans-national and virtual access (see Annex 2a of the Horizon Europe Model Grant Agreement). Specific conditions are described in the specific topic of the Work Programme.

Application form templates are available in the Submission System, including the Standard application form (HE RIA, IA) and Standard application form (HE CSA). Evaluation form templates will be used with the necessary adaptations, including the Standard evaluation form (HE RIA, IA) and Standard evaluation form (HE CSA).

Guidance documents include the HE Programme Guide, Model Grant Agreements (HE MGA, Lump Sum MGA, Framework Partnership Agreement FPA), Call-specific instructions, Detailed budget table (HE LS), Information on financial support to third parties (HE), Information on clinical studies (HE), and Guidance: "Lump sums - what do I need to know?".

Additional documents include the HE Main Work Programme 2026-2027 (General Introduction, Research Infrastructures, General Annexes), HE Programme Guide, HE Framework Programme 2021/695, HE Specific Programme Decision 2021/764, EU Financial Regulation 2024/2509, Decision authorising the use of lump sum contributions under the Horizon Europe Programme, Rules for Legal Entity Validation, LEAR Appointment and Financial Capacity Assessment, EU Grants AGA Annotated Model Grant Agreement, Funding & Tenders Portal Online Manual, Funding & Tenders Portal Terms and Conditions, and Funding & Tenders Portal Privacy Statement.

The budget overview lists several topics under the call, including:

HORIZON-INFRA-2026-01-EOSC-01: HORIZON Research and Innovation Actions with a budget of EUR 40,000,000, single-stage, with an indicative number of 1 grant.

HORIZON-INFRA-2026-01-EOSC-02: HORIZON Coordination and Support Actions with a budget of EUR 10,000,000, single-stage, with an indicative number of 2 grants, contributing EUR 3,000,000 to EUR 5,000,000 each.

HORIZON-INFRA-2026-DEV-01-01: HORIZON Research and Innovation Actions with a budget of EUR 10,000,000, single-stage, with an indicative number of 4 grants, contributing EUR 2,000,000 to EUR 3,000,000 each.

HORIZON-INFRA-2026-DEV-01-02: HORIZON Research and Innovation Actions with a budget of EUR 40,000,000, single-stage, with an indicative number of 6 grants, contributing EUR 4,000,000 to EUR 8,000,000 each.

HORIZON-INFRA-2026-DEV-01-03: HORIZON Research and Innovation Actions with a budget of EUR 9,900,000, single-stage, with an indicative number of 3 grants, contributing EUR 3,000,000 to EUR 4,500,000 each.

HORIZON-INFRA-2026-DEV-01-04: HORIZON Coordination and Support Actions with a budget of EUR 2,000,000, single-stage, with an indicative number of 1 grant, contributing around EUR 2,000,000.

HORIZON-INFRA-2026-DEV-01-05: HORIZON Research and Innovation Actions with a budget of EUR 8,000,000, single-stage, with an indicative number of 1 grant, contributing around EUR 8,000,000.

HORIZON-INFRA-2026-DEV-01-06: HORIZON Coordination and Support Actions with a budget of EUR 8,000,000, single-stage, with an indicative number of 5 grants, contributing EUR 1,000,000 to EUR 1,500,000 each.

HORIZON-INFRA-2026-DEV-01-07: HORIZON Research and Innovation Actions with a budget of EUR 10,000,000, single-stage, with an indicative number of 3 grants, contributing EUR 1,000,000 to EUR 4,000,000 each.

HORIZON-INFRA-2026-SERV-01-01: HORIZON Research and Innovation Actions with a budget of EUR 32,000,000, single-stage, with an indicative number of 1 grant, contributing around EUR 32,000,000.

HORIZON-INFRA-2026-TECH-01-01: HORIZON Research and Innovation Actions with a budget of EUR 110,000,000, single-stage, with an indicative number of 11 grants, contributing EUR 5,000,000 to EUR 10,000,000 each.

HORIZON-INFRA-2026-TECH-01-02: HORIZON Research and Innovation Actions with a budget of EUR 15,000,000, single-stage, with an indicative number of 2 grants, contributing EUR 5,000,000 to EUR 7,500,000 each.

In summary, this Horizon Europe call aims to bolster the EBRAINS Research Infrastructure, a key European asset for advancing neuroscience, brain medicine, and AI. It seeks proposals that will enhance the infrastructure's digital facilities, integrate AI tools, promote data sharing and interoperability, foster international collaborations, and develop training programs. The call encourages projects that align with the European Health Data Space and build synergies with other relevant research infrastructures, ultimately contributing to a better understanding of the human brain and improved brain health outcomes. The call is structured around several specific topics, each with its own budget and focus, spanning research and innovation actions as well as coordination and support activities.

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Breakdown

Eligible Applicant Types: The eligible applicant types are not explicitly defined in the provided text. However, based on the context of Horizon Europe Research and Innovation Actions (RIA) and Coordination and Support Actions (CSA), eligible applicants typically include universities, research institutes, SMEs, large enterprises, and other legal entities carrying out research and innovation activities. The mention of "industrial users" suggests that for-profit entities are also eligible.

Funding Type: The primary financial mechanism is a grant, specifically through Horizon Europe Research and Innovation Actions (RIA) and Coordination and Support Actions (CSA). The eligible costs may take the form of unit costs for trans-national and virtual access to research infrastructures as defined in the Decision authorising the use of unit costs for the actions involving trans-national and virtual access (see Annex 2a of the Horizon Europe Model Grant Agreement).

Consortium Requirement: The text does not explicitly state whether a single applicant or a consortium is required. However, given the scope and nature of the activities, particularly those involving the integration of diverse services and collaboration with multiple research infrastructures, a consortium is highly probable. Partner search announcements are available, suggesting that consortia are expected.

Beneficiary Scope (Geographic Eligibility): The primary geographic eligibility appears to be focused on European entities, given the emphasis on pan-European relevance and cooperation within Europe. However, the text mentions that "A number of non-EU/non-Associated Countries that are not automatically eligible for funding have made specific provisions for making funding available for their participants in Horizon Europe projects," indicating that some participation from non-EU/Associated Countries is possible, subject to specific provisions outlined in the Horizon Europe Programme Guide.

Target Sector: The program targets several interconnected sectors:
Neuroscience: Advancing scientific and technological discoveries in neurosciences.
Brain Medicine: Supporting medical innovation and improved diagnostics, therapies, and personalized treatment plans.
Brain-Inspired Cognitive Technologies: Fostering the translation of insights from neuroscience for novel AI, neuro-inspired computing, and neurorobotics.
Artificial Intelligence: Integrating AI tools to support intuitive interaction with users, facilitate brain research, data analysis, simulations, and biological modelling of the brain.
Health: Contributing to the European Health Data Space and advancing brain health research.
ICT: Implementing digital services to empower neuroscience research.
Robotics: Application in research, robotics, and neurotech.

Mentioned Countries: The text refers to "non-EU/non-Associated Countries" and "European countries".

Project Stage: The project stage appears to be focused on development, validation, and demonstration, with an emphasis on operating existing, improved, and new services within the EBRAINS Research Infrastructure. The call aims to scale up data integration and curation, demonstrate scalability and robustness of approaches, and develop robust and continuously available services.

Funding Amount: The funding amounts vary depending on the specific topic within the call:
HORIZON-INFRA-2026-01-EOSC-01: around €40,000,000
HORIZON-INFRA-2026-01-EOSC-02: €3,000,000 to €5,000,000
HORIZON-INFRA-2026-DEV-01-01: €2,000,000 to €3,000,000
HORIZON-INFRA-2026-DEV-01-02: €4,000,000 to €8,000,000
HORIZON-INFRA-2026-DEV-01-03: €3,000,000 to €4,500,000
HORIZON-INFRA-2026-DEV-01-04: around €2,000,000
HORIZON-INFRA-2026-DEV-01-05: around €8,000,000
HORIZON-INFRA-2026-DEV-01-06: €1,000,000 to €1,500,000
HORIZON-INFRA-2026-DEV-01-07: €1,000,000 to €4,000,000
HORIZON-INFRA-2026-SERV-01-01: around €32,000,000
HORIZON-INFRA-2026-TECH-01-01: €5,000,000 to €10,000,000
HORIZON-INFRA-2026-TECH-01-02: €5,000,000 to €7,500,000

Application Type: The application type is an open call, with a single-stage submission process.

Nature of Support: Beneficiaries will receive money in the form of grants to support their research and innovation activities.

Application Stages: The application process is single-stage.

Success Rates: The success rates are not explicitly mentioned.

Co-funding Requirement: The text does not explicitly mention a co-funding requirement.

Summary: This Horizon Europe call focuses on "Implementing digital services to empower neuroscience research for health and brain inspired technology via EBRAINS." It aims to support the EBRAINS Research Infrastructure by enhancing its digital facilities, integrating AI tools, and fostering collaboration within the European research community and beyond. The call seeks to advance scientific discoveries in neurosciences, brain medicine, and brain-inspired cognitive technologies, attracting a wide range of users, including industrial partners. Projects should operate and improve EBRAINS' digital infrastructure, support the use of its services, integrate AI tools for data analysis and modelling, demonstrate scalability and robustness, develop a collaborative platform for neuro-inspired AI, strengthen international collaborations, and provide tailored training programs. The call also emphasizes alignment with European efforts on health data sharing and synergy with other EU Research Infrastructures. Funding is provided through Horizon Europe Research and Innovation Actions (RIA) and Coordination and Support Actions (CSA), with varying budget allocations for different topics. The application process is a single-stage open call, and while co-funding is not explicitly mentioned, applicants should consult the Horizon Europe Programme Guide for detailed financial regulations.

Short Summary

Impact
This funding aims to enhance the EBRAINS Research Infrastructure by operating and developing digital services that empower neuroscience research for health and brain-inspired technology.
Applicant
Applicants should possess expertise in neuroscience research, advanced digital services, and the management of large-scale research infrastructures, including collaboration with industrial and clinical stakeholders.
Developments
The funding will support the development of digital infrastructure, AI integration, and collaborative platforms for neuroscience research and brain health.
Applicant Type
This funding is designed for research institutions, universities, public research organizations, private research entities, SMEs, large enterprises, non-profit organizations, and public-private partnerships.
Consortium
This funding requires a consortium of multiple applicants; single-applicant submissions are not permitted.
Funding Amount
The funding amount for this project is €32,000,000.
Countries
The relevant countries include EU Member States and associated countries, with Switzerland having equal standing in Horizon Europe.
Industry
The funding targets the neuroscience research and health sciences sectors, with a strong emphasis on artificial intelligence and advanced computing.

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